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| Registros recuperados : 4 | |
| 1. |  | DOURADO, C. P.; KAMIKAWACHI, R. C.; FERREIRA, M. J. P.; SARTORI, A. L. B.; RODRIGUES, C. M.; SPADARI, C. de C.; ISHIDA, K.; SANNOMIYA, M. Exploring antifungal potential: the flavonoid composition of Machaerium villosum extracts against Cryptococcus neoformans. Research, Society and Development, v. 13, n. 1, e1613144604, 2024.| Biblioteca(s): Embrapa Agroenergia. |
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| 2. | | SANNOMIYA, M.; RODRIGUES, C. M.; OLIVEIRA, G. C. A.; CARVALHO, J. C. S.; COSTA, L. S. DA; SPADARI, C. DE C.; FERREIRA, M. J. P.; VILEGAS, W.; ISHIDA, K. Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity. Journal of Ethnopharmacology, n. 297, e115534, 2022. 5 p.| Biblioteca(s): Embrapa Agroenergia. |
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| 3. | | SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019.| Biblioteca(s): Embrapa Agroenergia. |
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| 4. | | RODRIGUES, C. M.; BENTO, C. C.; MORAES, C. B.; GOMES, C.; IOSHINO, R. S.; FREITAS-JUNIOR, L. H.; SPADARI, C. de C.; ISHIDA, K.; VILEGAS, W.; CARVALHO, J. C. S.; FERREIRA, M. J. P.; CARBONE, V.; PIACENTE, S.; ANGELO, R. M. de; HONORIO, K. M.; SANNOMIYA, M. A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract. Fitoterapia, v. 173, Mar. 2024.| Biblioteca(s): Embrapa Agroenergia. |
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| Registros recuperados : 4 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroenergia. Para informações adicionais entre em contato com cnpae.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
20/02/2024 |
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Data da última atualização: |
22/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
RODRIGUES, C. M.; BENTO, C. C.; MORAES, C. B.; GOMES, C.; IOSHINO, R. S.; FREITAS-JUNIOR, L. H.; SPADARI, C. de C.; ISHIDA, K.; VILEGAS, W.; CARVALHO, J. C. S.; FERREIRA, M. J. P.; CARBONE, V.; PIACENTE, S.; ANGELO, R. M. de; HONORIO, K. M.; SANNOMIYA, M. |
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Afiliação: |
CLENILSON MARTINS RODRIGUES, CNPAE; CHARLYANA CARVALHO BENTO, UNIVERSIDADE DE SÃO PAULO; CAROLINA BORSOI MORAES, UNIVERSIDADE DE SÃO PAULO; CECILIA GOMES, UNIVERSIDADE DE SÃO PAULO; RAFAELLA SAYURI IOSHINO, UNIVERSIDADE DE SÃO PAULO; LUCIO H. FREITAS-JUNIOR, UNIVERSIDADE DE SÃO PAULO; CRISTINA DE CASTRO SPADARI, UNIVERSIDADE DE SÃO PAULO; KELLY ISHIDA, UNIVERSIDADE DE SÃO PAULO; WAGNER VILEGAS, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO.; JULIANA CAJADO SOUZA CARVALHO, UNIVERSIDADE DE SÃO PAULO; MARCELO JOSÉ PENA FERREIRA, UNIVERSIDADE DE SÃO PAULO; VIRGINIA CARBONE, Institute of Food Sciences; SONIA PIACENTE, UNIVERSITY OF SALERNO; RAFAELA MOLINA DE ANGELO, UNIVERSIDADE DE SÃO PAULO; KATHIA MARIA HONORIO, UNIVERSIDADE DE SÃO PAULO; MIRIAM SANNOMIYA, UNIVERSIDADE DE SÃO PAULO. |
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Título: |
A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Fitoterapia, v. 173, Mar. 2024. |
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DOI: |
https://doi.org/10.1016/j.fitote.2024.105820 |
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Idioma: |
Inglês |
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Conteúdo: |
In this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the methanolic leaf extract of B. coccolobifolia exhibits antifungal activity against Cryptococcus neoformans (IC50 = 4 μg/mL). Additionally, docking studies were conducted to elucidate the interactions between the identified compounds and the central residues at the binding site of biological targets associated with COVID-19. Furthermore, the extract demonstrated an in vitro half maximum effective concentration (EC50 = 7 μg/mL) and exhibited significant selectivity (>90%) toward SARS-CoV-2. |
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Palavras-Chave: |
COVID-19. |
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Thesaurus NAL: |
Antifungal agents; Antifungal properties; Byrsonima; Flavonoids. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 02178naa a2200373 a 4500
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100 1 $aRODRIGUES, C. M.
245 $aA potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract.$h[electronic resource]
260 $c2024
520 $aIn this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the methanolic leaf extract of B. coccolobifolia exhibits antifungal activity against Cryptococcus neoformans (IC50 = 4 μg/mL). Additionally, docking studies were conducted to elucidate the interactions between the identified compounds and the central residues at the binding site of biological targets associated with COVID-19. Furthermore, the extract demonstrated an in vitro half maximum effective concentration (EC50 = 7 μg/mL) and exhibited significant selectivity (>90%) toward SARS-CoV-2.
650 $aAntifungal agents
650 $aAntifungal properties
650 $aByrsonima
650 $aFlavonoids
653 $aCOVID-19
700 1 $aBENTO, C. C.
700 1 $aMORAES, C. B.
700 1 $aGOMES, C.
700 1 $aIOSHINO, R. S.
700 1 $aFREITAS-JUNIOR, L. H.
700 1 $aSPADARI, C. de C.
700 1 $aISHIDA, K.
700 1 $aVILEGAS, W.
700 1 $aCARVALHO, J. C. S.
700 1 $aFERREIRA, M. J. P.
700 1 $aCARBONE, V.
700 1 $aPIACENTE, S.
700 1 $aANGELO, R. M. de
700 1 $aHONORIO, K. M.
700 1 $aSANNOMIYA, M.
773 $tFitoterapia$gv. 173, Mar. 2024.
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